What is malignant HTA?

➢Malignant hypertension, defined as blood pressure usually greater than 200/120 mm Hg ➢The prevalence of malignant hypertension is higher in developing countries. ➢ It may present with severe acute kidney injury and renal failure. ➢Renal changes are confined to the vasculature and may include thrombotic microangiopathy. ➢ Injury resulting from long-standing hypertension causes\increased permeability of the vessels to fibrinogen and other plasma proteins,endothelial injury, and platelet deposition. ➢This leads to the appearance of fibrinoid necrosis of arterioles and small arteries and intravascular thrombosis ➢Because of the luminal narrowing, the kidneys become markedly ischemic, which leads to further elevation of blood pressure via the renin-angiotensin system