How is morphology of TMA?

Light Microscopy : ➢ lesions affect arterioles and / or glomeruli Plump Endothelial cells Subendothelial edema; fibrin and / or platelet thrombi concentric hyperplasia of arteriolar myocytes ("onion bulb" appearance); chronic fibrous glomerular and arteriolar sequelae. IF : Fibrine thrombi de fibrine In children, Kidney biopsy is not mandatory in case of a typical clinical setting : HUS following a GI infection