How is morphology of glioblastoma?

➢ T2-weighted MRI image in axial view shows a large infiltrative mass ➢ With central necrosis, edema, and an irregular border. ➢ For not resectable, radiation and chemotherapy may add months to patient survival. ➢ Gliomas may begin as low-grade neoplasms that often have TP53 mutations, and as they progress to higher-grade lesions ➢ Highly cellular neoplasm with marked hyperchromatism and pleomorphism. ➢ Prominent vascularity and area of pale necrosis with neoplastic cells concentrated around it. ➢ Pseudopalisading necrosis is characteristic of glioblastoma. ➢The cells can infiltrate widely, particularly along white matter tracts, and even through the CSF. ➢Such highly anaplastic cells may be difficult to differentiate from metastases, but gliomas should be GFAP positive with immunohistochemistry.