How is effector phase of T1HS?

Effector phase includes all the body’s complex reactions to the potent chemicals from the granules Preformed components that are released from granules include histamine, serotonin, and bradykinin. Selected Preformed Components of Mast Cell Granules include: Heparin (stimulated bradykinin: increased vascular permeability, vasodilation, bronchiole constriction, mucus) Histamine (smooth muscle contraction, vascular permeability, mucus and tears) Serotonin (vasodilation and smooth muscle contraction) Also release lipid mediators (LT and PG) and cytokines (TNF) have potent local effect cause vascular leak, muscle contraction and movement of granulocytes.