What is TII HS CDR?

➢ Antibodies IgG or IgM, generated against cell surface antigens, may be cytotoxic (type IIA) or may have agonistic/antagonistic properties (type IIB) or they are generated against extracellular matrix proteins ➢ The resulting Ag-Ab complexes activate complement (via the classic pathway), leading to cell lysis or extracellular tissue damage. ➢ The target can be a red cell, a virally infected cell, or a bacterium. Type IIA /Autoantibodies against blood cells promote their destruction ➢ IgG or IgM responses to antigens located on the cell surface lead to the rapid destruction of these cells.