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Clinical Immunology

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Question:

What are S&S associated with transfusion reactions?

Author: H K



Answer:

1) Inflammatory: Fever/chills, Skin changes (anemia, jaundice), Pain at infusion site 2) Circulatory: Blood pressure changes, Shock, Hemoglobinemia/uria 3) Pulmonary: Dyspnea, orthopnea, wheezing Full respiratory failure 4) Coagulation: Unexplained increase in bleeding DIC 5) Psychological: a) Sense of unease or impending “doom”! ➢ The symptom include nausea and vomiting, and pain in the back and chest. ➢ These acute transfusion reactions are often seen in previously unsensitized individuals ➢ Other blood groups, minor blood group systems, induce IgG antibodies, which cause less agglutination than IgM. ➢ Transfusion reactions caused by the minor blood groups are relatively rare, unless repeated transfusions are given


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H K
H K