How is presentation of IT?

➢ Typically, it is chronic in adults, but it is usually acute and self-limited in children. In adults, most cases of ITP are chronic, manifesting with an insidious onset, and occur in middle-aged women. In chronic ITP, for unknown reasons, membrane glycoproteins (GPs) on the surface of platelets become immunogenic, stimulating the production of platelet autoantibodies ➢ In children, most cases of immune thrombocytopenic purpura (ITP) are acute, manifesting a few weeks after a viral illness; peripheral smear shows an increased number of normal or atypical lymphocytes reflecting a recent viral illness). In acute ITP, the stimulus for autoantibody production is unknown; pseudoantigens may be formed by the passive adsorption of pathogens on platelet surfaces