What are diseases caused by antireceptor Abs Type II HS?

Autoantibodies against cell surface receptors produce disease by stimulating or blocking receptor function. Diseases caused by this mechanism include: – Myasthenia gravis: acetylcholine receptor antibody. – Graves disease (thyrotoxicosis): anti-TSH receptor antibody. – Pernicious anemia: anti-parietal cell antibody myasthenia gravis, autoantibodies against the acetylcholine receptors on skeletal muscle cells bind the receptor and induce its internalization and degradation in lysosomes, reducing the efficiency of neuromuscular transmission and causing progressive muscle weakness Graves' disease is characterized by autoantibodies that act as agonists. TSH receptor antibodies (TRAb) are believed to cause hyperthyroidism of Graves ' disease