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Clinical Immunology

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Question:

How is good pasture disease example of TIIHS?

Author: H K



Answer:

Goodpasture's disease, in which antibodies against the α3-chain of type IV collagen (the collagen in basement membranes) are deposited in glomerular and lung basement membrane. Goodpasture disease is a term used to describe glomerulonephritis, with or without pulmonary hemorrhage, and the presence of circulating anti– glomerular basement membrane (anti-GBM). ➢ Although anti-GBM disease is seen as a prototypic autoantibody-mediated disease, T cells have a vital role in disease initiation and progression. ➢ T cells enhance B-cell function and antibody production and may play a direct pathogenic role in kidney and lung injury. Environmental insult + genetics


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H K
H K