How is pathophysiology of TIII HS?

The cause of damage is a result of the action of cleaved complement C3a and C5a, which mediate the induction of granule release from mast cells (from which histamine can cause urticaria)…and recruitment of inflammatory cells (predominantly neutrophils ) into the tissue mainly those with lysosomal action, leading to tissue damage through “frustrated phagocytosis” by neutrophils and macrophages Macrophages and neutrophils in particular play a central role in the inflammatory process by releasing proteins and small-molecule inflammatory mediators that control infection but can damage host tissue. ➢ Such reactions progressing to the point of disease produce IC diseases. ➢ Damage caused are due to innocent bystander lysis Cause platelet aggregation, clotting factor, microthrombus mostly w/in vessels