How is presentation of TIII HS?

➢ The reaction can take hours, days, or even weeks to develop, depending on whether or not there is immunologic memory of the precipitating antigen. ➢ Typically, clinical features emerge a week following initial antigen challenge, when the deposited IC can precipitate an inflammatory response ➢ The severity may be dependent on the quantity & distribution of IC – Widespread inflammation wherever complexes deposits through blood – Localized inflammation if at the site of antigen entry. ➢ The principal feature that separates type III reactions from other hypersensitivity reactions is that in type III reaction, the antigen-antibody complexes are pre-formed in the circulation before their deposition in tissues