How is pathophysiology of LCV?

➢ IC deposition, with resultant neutrophil chemotaxis and release of proteolytic enzymes and free oxygen radicals, is a key component in the pathophysiology of LCV. ➢ However, the exact mechanisms remain unknown ➢ Systemic symptoms noted with leukocytoclastic vasculitis may include low-grade fevers, malaise, weight loss, myalgias, and arthralgias ➢ LCV may be localized to the skin or may be associated with systemic involvement. Internal disease most often manifests in the joints, the gastrointestinal (GI) tract, and the kidneys ➢ LCV may be acute or chronic. Patients with chronic disease may experience persistent lesions or intermittent recurrence ➢ Hypersensitivity vasculitis occurs in 10-30 persons per million persons per year.