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Clinical Immunology

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Question:

What are some examples of polysaccharide conjugated to protein vaccines?

Author: H K



Answer:

Hib vaccine: Polysaccharides conjugated to a protein carrier • The polysaccharide (PS) alone may activate B in a Tindependent manner, without memory • PS conjugated to a carrier protein (tetanus or diphtheria toxoid) induces a T-dependent antibody response with memory Vaccine against hepatitis B virus — History: — HB virus discovered in 1965 (Australia Antigen) — 1st vaccine (1969): inactivated virus purified from serum of infected individuals — 2nd vaccine (1986): recombinant protein prepared by genetic engineer


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H K
H K