What are the two types of tumor antigens?

Tumor specific antigens (TSA): excellent targets — Viral antigens: ex HBV antigens in liver carcinoma — Neoantigens: derive from mutated genes (oncogenes, tumor suppressor genes or others): ex: ras, p53 Tumor associated antigens (TAA): less immunogenic, more challenging to target — Over- or aberrantly expressed proteins. Ex: VEGF — Cell type-specific differentiation antigens: normal cell proteins characteristic of a given maturation stage of a cell type. Ex: CD20, CALLA (CD10) — Oncofetal antigens: fetal proteins normally silenced in adult cells, but reexpressed after epigenetic alterations — Cancer-testis antigens: Ags present in normal germ cells of testis and ovary, and in fetus but not adults reappear in cancer.