Question:
What are mechanisms of action of naked Abs?
Author: H KAnswer:
Effector functions : Complement activation (CDC) NK cell activation (ADCC) Ex: Rituximab (Rituxan) : anti-CD20 approved in 1997 for NonHodgkin lymphoma Modulation of Ligand-Receptor interaction: Agonist or antagonist effect on a receptor of cytokine, growth factor, hormone…. Ex: Trastuzumab (Herceptin) anti-ErbB2 (or HER-2), approved in 1998 for treatment of breast cancer Ex: Bavacizumab (avastin): anti-VEGF (vascular endothelial growth factor, treatment of colon cancer) approved in 2018
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