Question:
It was determined that 95% of an oral 80-mg dose of verapamil was absorbed in a 70-kg test subject. However, because of extensive biotransformation during its first pass through the portal circulation, the bioavailability of verapamil was only 25%. Assuming a liver blood flow of 1500 mL/min, the hepatic clearance of verapamil in this situation was
Author: Jearrie Jean Sumagang![It was determined that 95% of an oral 80-mg dose of verapamil was
absorbed in a 70-kg test subject. However, because of extensive biotransformation during its first pass through the portal circulation, the bioavailability
of verapamil was only 25%. Assuming a liver blood flow of 1500 mL/min,
the hepatic clearance of verapamil in this situation was](https://markdown.memory.com/assets/uploadImageUrl__0x600__25aaa253-ef0e-4f31-a9d7-cbce546ba8ff_1591413549977617402_.jpg)
Answer:
1425 mL/min
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Jearrie Jean Sumagang![Jearrie Jean Sumagang](https://markdown.memory.com/profile-pictures/1056703-profile-picture-3183d0c1-f148-4363-adb6-bbcccf66d8ca.jpg)