Toxicity pyrazinamide

Approximately 40% of patients develop nongouty polyarthralgia urate accumulation leads to gout hyperurecemia one in 5 people experience liver dysfunction Other adverse effects are myalgia, gastrointestinal irritation, maculopapular rash, hepatic dysfunction, porphyria, and photosensitivity reactions. Pyrazinamide should be avoided in pregnancy.