Rifabutin

It is a derivative of rifampin, is the preferred drug for use in tuberculosis-infected patients with (HIV), who are concomitantly treated with protease inhibitors or nonnucleoside reverse transcriptase inhibitors, because it is a less potent inducer of cytochrome P450 enzymes. Rifabutin has adverse effects similar to those of rifampin, but can also cause uveitis, skin hyperpigmentation, and neutropenia.