Fomivirsen

Fomivirsen is an antisense oligonucleotide that binds to mRNA of CMV, inhibiting early protein synthesis. The drug is injected intravitreally for treatment of CMV retinitis. Concurrent systemic anti-CMV therapy is recommended to protect against extraocular and contralateral retinal CMV disease. Fomiversin causes iritis, vitreitis, increased intraocular pressure and changes in vision It is an antisense oligonucleotide directed against CMV mRNA. Its use is limited to those who cannot tolerate or have failed other therapies for CMV retinitis. A 2 to 4-week hiatus after discontinuing cidofovir is desirable to reduce toxicity. The drug is administered intravitreally. The common adverse effects include iritis, vitritis, and changes in vision.