Pharmacokinetics interferon

There are several forms of IFN-α with minor differences in amino acid composition. Absorption from intramuscular or subcutaneous injection is slow; elimination of IFN-α is mainly via proteolytic hydrolysis in the kidney. Conventional forms of IFN-α are usually administered daily or 3 times a week. Pegylated forms of IFN-α conjugated to polyethylene glycol can be administered once a week.