Terabinafine uses

Oral terbinafine is the drug of choice for treating dermatophytoses and, especially, onychomycoses (fungal infections of nails). It is better tolerated, requires shorter duration of therapy, and is more effective than either itraconazole or griseofulvin Terbinafine inhibits fungal squalene epoxidase,thereby decreasing the synthesis of ergosterol This plus the accumulation of toxic amounts of squalene result in the death of the fungal cell. [Note: Significantly higher concentrations of terbinafine are needed to inhibit human squalene epoxidase, an enzyme required for the cholesterol synthetic pathway.] Topical terbinafine is active against Trichophyton rubrum and Trichophyton mentagrophytes . It may also be effective against Candida albicans, Epidermophyton floccosum,and Scopulariopsis brevicaulis, but the safety and efficacy in treating clinical infections due to these pathogens has not been established.Topical terbinafine 1% cream and solution are used to treat tinea pedis, tinea corporis, and tinea cruris. Therapy is prolonged (usually about 3 months) but considerably shorter than that with griseofulvin