Griseofulvin mechanism

Griseofulvin accumulates in newly synthesized, keratin-containing tissue, where it causes disruption of the mitotic spindle and inhibition of fungal mitosis Duration of therapy is dependent on the rate of replacement of healthy skin and nails. Ultrafine crystalline preparations are absorbed adequately from the gastrointestinal tract, and absorption is enhanced by high-fat meals. Griseofulvin induces hepatic CYP450 activity. It also increases the rate of metabolism of a number of drugs, including anticoagulants. It may exacerbate intermittent porphyria Oral absorption of griseofulvin depends on the physical state of the drug—ultra-micro-size formulations, which have finer crystals or particles, are more effectively absorbed—and is aided by high-fat foods. Griseofulvin requires treatment of 6 to 12 months in duration. The drug is distributed to the stratum corneum, where it binds to keratin. Biliary excretion is responsible for its elimination.