Iodoquinol

Iodoquinol, a halogenated hydroxyquinoline, is an orally active luminal amebicide used as an alternative to diloxanide for mildto-severe intestinal infections. Adverse gastrointestinal effects are common but usually mild, especially when taken with meals.Systemic absorption after high doses may lead to thyroid enlargement, skin reactions due to iodine toxicity and possibly neurotoxic effects, including peripheral neuropathy and visual dysfunction. It is a halogenated 8-hydroxy quinolone, is amebicidal against E. histolytica and is effective against the luminal trophozoite and cyst forms. Side effects from iodoquinol include rash, diarrhea, and dose-related peripheral neuropathy, including a rare optic neuritis. Long-term use of this drug should be avoided.