Advere effects melarsoprol

CNS toxicities are the most serious side effects of melarsoprol treatment. Encephalopathy may appear soon after the first course of treatment but usually subsides. In rare cases, however, it may be fatal. Hypersensitivity reactions may also occur, and fever may follow injection. Gastrointestinal disturbances, such as severe vomiting and abdominal pain, can be minimized if the patient is in the fasting state during drug administration and for several hours thereafter. Melarsoprol is contraindicated in patients with influenza. Hemolytic anemia has been seen in patients with glucose-6-phosphate dehydrogenase deficiency.