Nifurtimox adverse effects

Adverse effects are common following chronic administration, particularly among the elderly. Major toxicities include immediate hypersensitivity reactions such as anaphylaxis; delayed hypersensitivity reactions, such as dermatitis and icterus; and gastrointestinal problems, cns effects that may be severe enough to cause weight loss. Peripheral neuropathy is relatively common, and disturbances in the CNS may also occur. In addition, cell-mediated immune reactions may be suppressed.