Floxuridine

Floxuridine  is an analog (floxuridine is 2’-deoxy-5-fluorouridine ) of 5-FU. When given by rapid intraarterial injection, floxuridine is rapidly catabolized in the liver to 5-FU and produces antimetabolite effects. The primary effect is to interfere with the synthesis of DNA and, to a lesser extent, inhibit the formation of RNA. The drug is excreted intact and as fluorouracil, urea, and α-fluoro-β-alanine in the urine. Floxuridine is effective in the palliative management of GI adenocarcinoma that has metastasized to the liver. The common adverse effects are nausea, vomiting, diarrhea, enteritis, stomatitis, and localized erythema.