Busulfan

Busulfan is another oral agent that is effective against chronic granulocytic leukemia. Busulfan is also a bifunctional alkylating agent that can cause myelosuppression. In aged patients, busulfan can cause pulmonary fi brosis. Like other alkylating agents, all of these agents are leukemo genic.Busulfan is sometimes used in chronic myelogenous leukemia. It causes adrenal insufficiency, pulmonary fibrosis, and skin pigmentation.