Duloxetine side effect

Side effects are common with duloxetine, including nausea, dry mouth, and constipation. Diarrhea and vomiting are seen less often. Insomnia, dizziness, somnolence, and sweating are also seen. Sexual dysfunction also occurs along with the possible risk for an increase in either blood pressure or heart rate. Duloxetine is a moderate inhibitor of CYP2D6 and CYP3A4 isoenzymes.Duloxetine is also reported to cause liver dysfunction.