Rufinamide pharmacokinetics adverse effects

Serum concentrations of rufinamide are affected by other antiseizure medications. It is induced by carbamazepine and phenytoin and inhibited when given with valproate. Women taking birth control tablets should be counseled that they may not be effective when used concurrently with rufinamide. Adverse effects include the potential for shortened QT intervals. Patients with familial short QT syndrome should not be treated with rufinamide.it is a weak inhibitor of CYP2E1 and a weak inducer of CYP3A4 enzymes.