Buprenorphine is classified as a partial agonist, acting at the µ receptor. It acts like morphine in naïve patients, but it can also precipitate withdrawal in morphine users. A major use is in opiate detoxification, because it has a less severe and shorter duration of withdrawal symptoms compared to methadone. It causes little sedation, respiratory depression, and hypotension, even at high doses. In contrast to methadone, which is available only at specialized clinics, buprenorphine is approved for office-based detoxification or maintenance. Buprenorphine is administered sublingually, parenterally, or transdermally and has a long duration of action because of its tight binding to the μ receptor. The tablets are indicated for the treatment of opioid dependence and are available in buprenorphine alone (Subutex) and also in a combination product containing buprenorphine and naloxone (Suboxone). Naloxone was added to buprenorphine to prevent the abuse of buprenorphine via IV administration.