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From course:

Immunology chapter 1-3

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Question:

What are Killer cell Immunoglobulin-like Receptors KIRs?

Author: Shay 1vcc



Answer:

Involved in negative signaling Killer cell Immunoglobulin-like Receptors (KIRs) e.g. CD94 + NKG2. Receptors sense normal MHC molecules on healthy cells causing NK cells to shut off. If virus shuts off MHC expression to evade cytotoxic T cells, NK cells will notice MHC is missing and if activation signals are present, NK cell will be activated and cell is killed – “Recognition of Missing Self”


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Shay 1vcc
Shay 1vcc