Question:
What are Killer cell Immunoglobulin-like Receptors KIRs?
Author: Shay 1vccAnswer:
Involved in negative signaling Killer cell Immunoglobulin-like Receptors (KIRs) e.g. CD94 + NKG2. Receptors sense normal MHC molecules on healthy cells causing NK cells to shut off. If virus shuts off MHC expression to evade cytotoxic T cells, NK cells will notice MHC is missing and if activation signals are present, NK cell will be activated and cell is killed – “Recognition of Missing Self”
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