What’s the restrictions of MHC ?

T cells recognize antigens only when antigens presented by MHC molecules MHC molecules can bind and display Specific short peptides Binding take place inside APC T-cell receptors recognize MHC and bound peptide Each MHC molecule displays one peptide at a time Class I and Class II MHC molecules load peptides from different cellular compartments. Stable surface expression of MHC molecule requires bound peptide