Pathophysiology of IBS based on physiological factors (Give one only)

Altered intestinal motility - postprandial pain - ingestion of food high in FODMAPs (Fermentable Oligosaccharide Disaccharide Monosaccharide and Polyols) are poorly absorbed in small intestine results in increase colonic motility and secretion Increase intestinal sensitivity - hypersensitivity to normal amount of intraluminal secretion - increased pain perception to the presence normal intestinal gas - rectal sensitivity during menses Genetic/ environmental factors - began after acute gastroenteritis