The FATE of chaperone client proteins is not pre-determined

The prevailing concentrations of Hsc70 and Hsp90 co-chaperones determine the proportion of an unfolded/misfolded protein that can gain a stable conformation and the proportion that is destroyed. n other words: co-chaperones make decisions by competing to release chaperone clients. There is an interacting, competing network of co-chaperones that determines the fate of a chaperone client