What happens blood glucose levels decrease (not eating )

Blood glucose levels DECREASE (not eating/fasting/exercise) The pancreas detects the DECREASE in blood glucose. The alpha cells of the pancreas release GLUCAGON Glucagon is released into the blood and moves to the liver. Glucagon binds to the specific Glucagon receptor proteins in the liver cell membrane. This activates the second messenger model. Binding of glucagon activated adenylate cyclase (enzyme) which converts ATP in cAMP. cAMP activates protein kinase A (enzyme) which activates a cascade of enzyme reactions. The enzymes hydrolyse glycogen into glucose (glycogenolysis) The glucose moves out of liver cells through channel proteins in the liver cell membrane and into the blood. This increases the blood glucose level. . Gluconeogenesis also occurs – new glucose molecules produced from amino acids/glycerol. 6. These negative feedback mechanisms INCREASE the blood glucose levels back to normal.