Anti-platelet •MOA: irreversibly inhibits platelet COX so that it's effect lasts 8-10 days (THE LIFE OF THE PLATELET) decreases the incidence of TRANSIENT ISCHEMIC ATTACKS, UNSTABLE ANGINA, CORONARY ARTERY THROMBOSIS WITH MYOCARDIAL INFARCTION and THROMBOSIS after coronary artery bypass grafting long-term use is associated with LOWER INCIDENCE OF COLON CANCER