Question:
Give an example of acetylation.
Author: H KAnswer:
Isoniazid (INH) chemotherapy tx of TB, primary step of its metabolism is acetylation by (NAT2) forming acetyl-INH. So we have fast acetylators and slow ones which will affect the half life of the drugs, causing higher risk of drug toxicity for slow acetylators due to higher half-lifes.
0 / 5 Â (0 ratings)
1 answer(s) in total
Author
H K![H K](https://lh4.googleusercontent.com/-V3rEIOcuFis/AAAAAAAAAAI/AAAAAAAAAAA/AMZuucnhTzvoiq2vqvBJhe7t9kqRkO_jNw/s96-c/photo.jpg)