How is the tx of AIH?

Prednisone and azathioprine (mainstays of therapy) Absolute indications for therapy (serum AST >10x normal, or serum AST >5x normal +gamma globulin >2x normal, or bridging necrosis on histology) Relative indications (symptoms, serum AST/globulin elevated less than absolute level, interface hepatitis) We can give monotherapy of prednisone (cases of cytopenia, pregnancy, malignancy and short course- week 1 60, than 2 40, 3 30, 4 30, and maintenance at 20) Or bitherapy (prednisone+aza, in cases of postmenopause, osteoporosis, DM, obesity, emotional lability, HTN, always give 50A, week 1 pred 30, 2 20, 3 15, 4 15, maintenance 10)