Question:
How is reverse cholesterol transport mechanism?
Author: H KAnswer:
Activated PPARa will cause release of free cholesterol outside cells (efflux), which will lead to LCAT activation to convert pre-b-HDL into HDL, thus HDL will increase (rich in ApoAI and II), go to liver cells, and increase cholesterol catabolism and elimination (important mechanism for hypercholesterolism
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