How is angiogenesis?

Critical for healing, development of collaterals, tumor increase size using other blood supply than original one. Involves sprouting new vessels from old one. Steps: Vasodilation by NO increased permeability by VEGF, separation of pericytes from albumin surface allowing vessel sprout, migration of endothelia to tissue injury, proliferation of endothelia just behind tip of migrating cells, remodeling into capillary tube, recruitment of periendothelial cells (smooth muscle, pericytes) to form vessel, suppression of endothelia proliferation and migration and deposition of basement membrane)