How is hyperproduction and decreased clearance of gout and local conditions causing gout?

Hyperproduction (increased purines [tumors, hematologic disease, chemo, psoriasis, food and beer], enzymatic defects [Lesch-Nyhan in boys, G6PD]) Decreased clearance (most common cause of gout, CKD, metabolic syndrome, HTN, decompensated HF, saturnine gout, alcohol, drugs [diuretics, aspirin, cyclosporine], genetics) Local conditions (Preference of lower limb [due to repititive microtrauma], osteoarthritis, cold temperature, severe intercurrent disease [hypoxia of tissue], surgery, uricosic drugs, some food?