How is pathophysiology of gout?

Formation of MSU crystals (hyperuricemia, precipitation of MCU crystals and deposition in articular and periarticular tissues) Acute gout attack (phagocytosis of the crystals, cell swelling and inflammation, cytokine production and vasodilation leading to neutrophil and monocyte influx) Chronic tophaceous gout (neutrophil death by NETosis, packaging of MSU crystals , inactivation of cytokines and resolution of inflammation) Normal uric acid is 6-6.6 mg/dl in serum, they accumulate in blood and tissues, precipitate in suprasaturated tissues form needle shaped crystals, they are less soluble under acid and low temperature conditions (cool peripheral joints). Urate crystals are recognized by polarizing microscopy by light retarding characteristic of urate.