What is calcium pyrophosphate deposition disease?

Metabolic arthropathy caused by deposition of CPD in and around joints especially articular and fibrocartilage, often asymptomatic, with only radio changes seen, various clinical manifestations may occur include acute (pseudogout) and chronic arthritis. Almost any joint involved mostly knees, wrists and hips, it is most common cause of secondary metabolic osteoarthritis. Five common presentations (asymptomatic [lanthanic] CPPD, acute pseudogout, pseudoosteoarthritis, pseudorheumatoid arthritis, pseudoneuropathic joints) Prognosis (significant morbidity due to acute attack pain, tx is important to prevent further end-organ damage but cannot reverse the joint disease)