TOXICOLOGY: 1 Metabolism and MOA: Undergoes oxidation via cytochrome P450s, with a small proportion being conjugated with glutathione (GSH pathway) – as a result it will be converted into Trichloroethanol and Chloroform.

The poisoning and toxicity is caused by metabolites rather than its parent compound.

Question

1 Metabolism and MOA: Undergoes oxidation via cytochrome P450s, with a small proportion being conjugated with glutathione (GSH pathway) – as a result it will be converted into Trichloroethanol and Chloroform.

The poisoning and toxicity is caused by metabolites rather than its parent compound.

LEIGHTON DWIGHT OBILLOS · Accepted Answer

•	Trichloroethylene (TCE)

TOXICOLOGY

1 Metabolism and MOA: Undergoes oxidation via cytochrome P450s, with a small proportion being conjugated with glutathione (GSH pathway) – as a result it will be converted into Trichloroethanol and Chloroform. The poisoning and toxicity is caused by metabolites rather than its parent compound.

• Trichloroethylene (TCE)

Author