What are fibrates?

Fibrates activate PPAR (peroxisome proliferator-activated receptors) The PPARs are a class of intracellular receptors that regulates carbohydrate and fat metabolism and adipose tissue differentiation Activation of PPARs causes transcription of a number of genes that facilitate lipid metabolism Upon binding to its natural ligand (fatty acids or eicosanoids) or hypolipidemic drugs ➔PPARs are activated In particular, PPARs regulates the expression of genes encoding for proteins involved in lipoprotein structure and function Fibrates bind to PPARα- mainly in liver and adipose tissue