What is the mechanism of action of fibrate?

Fibrates bind to PPARα- mainly in liver and adipose tissue  Increased LPL Lipoprotein lipase synthesis: increase hydrolysis of Chylomicrons and VLDL  Stimulated synthesis of Acyl-CoA dehydrogenases involved in fatty acid oxidation: decrease of TGs liver synthesis so decrease of VLDL production  Stimulation of apoA-I and apoA-II expression so increase HDL levels