How is tx of PCT?

• Phlebotomy reduces iron stores, which improves heme synthesis disturbed by ferro-mediated inhibition of uroporphyrinogen decarboxylase (UROD) • Oral chloroquine phosphate (125-250 mg PO twice weekly) or hydroxychloroquine sulfate (100-200 mg PO 2-3 times/wk), doses much lower than those used for antimalarial or photoprotective indications