What is Burkitt lymphoma?

• African (endemic) • Sporadic (nonendemic) • Aggressive subset in HIV IG::MYC rearrangement: Translocations of the c-MYC gene on Chromosome 8 t(8,14) Risk factors for endemic BL are Plasmodium falciparum (malaria) and EBV infections. Essentially all endemic tumors are infected with EBV Clinical features: most present as tumor at extranodal site - Endemic = mandible, abd viscera - Sporadic = ileo-cecum, peritoneum