How is microscopy of neuroblastoma?

Small, primitive-appearing cells with dark nuclei, scant cytoplasm, and poorly defined cell borders growing in solid sheets Mitotic activity, nuclear breakdown (karyorrhexis), and pleomorphism may be prominent. The background often demonstrates a faintly eosinophilic fibrillary material (neuropil) that corresponds to neuritic processes of the primitive neuroblasts. Typically, so-called Homer-Wright pseudo-rosettes can be found in which the tumor cells are concentrically arranged about a central space filled with neuropil (the absence of an actual central lumen garners the designation “pseudo-”).