How is pathogenesis of testicular cancer germ cell neoplasia?

➢ Germ cell neoplasia in situ is a precursor lesion present in conditions associated with a high risk for developing germ cell tumors ➢ GCN exhibits the same abnormality of chromosome 12 that is characteristic of fully developed germ cell tumors. ➢ As might be expected, germ cell neoplasia in situ often is found in “normal” testis adjacent to full-blown germ cell tumors. ➢ Testicular germ cell tumors are subclassified into seminomas and nonseminomatous germ cell tumors ➢ Seminomas are most common, accounting for about 50% of Testicular Germ Cell Neoplasm . ➢ They are histologically identical to tumors called dysgerminomas, which occur in the ovary, and germinomas, which occur in the central nervous system and other extragonadal sites.